This is the follow up to The Rosie Project, which has been wildly popular. I don't think you have to read The Rosie Project to enjoy the sequel, but if you haven't read the first book, I would recommend that you do, because it is so darn funny.
In the Rosie Project, brilliant but socially awkward Professor Don Tillman, a bachelor at 41, decides it is time to mate. He devises a survey for prospective mates to complete, a survey that is so scientifically devised and mathematically valid that he is sure he will find his perfect match. Let's just say that the woman he falls in love with does not fit his precisely delineated criterion - at all.
In the Rosie Effect, Professor Don Tillman and Rosie are married, and have moved to Manhattan. He has done his best to adjust to the unpredictabililty that comes with married life, and for Don, is coping rather well. Until of course, the unexpected occurs...
A good light read, a worthy sequel to the original, highly recommended.